Image and Video Processing (eess.IV)

Abstract: Optical Coherence Tomography (OCT) is a novel and effective screening tool for ophthalmic examination. Since collecting OCT images is relatively more expensive than fundus photographs, existing methods use multi-modal learning to complement limited OCT data with additional context from fundus images. However, the multi-modal framework requires eye-paired datasets of both modalities, which is impractical for clinical use. To address this problem, we propose a novel fundus-enhanced disease-aware distillation model (FDDM), for retinal disease classification from OCT images. Our framework enhances the OCT model during training by utilizing unpaired fundus images and does not require the use of fundus images during testing, which greatly improves the practicality and efficiency of our method for clinical use. Specifically, we propose a novel class prototype matching to distill disease-related information from the fundus model to the OCT model and a novel class similarity alignment to enforce consistency between disease distribution of both modalities. Experimental results show that our proposed approach outperforms single-modal, multi-modal, and state-of-the-art distillation methods for retinal disease classification. Code is available at https://github.com/xmed-lab/FDDM.

Abstract: Image synthesis is increasingly being adopted in medical image processing, for example for data augmentation or inter-modality image translation. In these critical applications, the generated images must fulfill a high standard of biological correctness. A particular requirement for these images is global consistency, i.e an image being overall coherent and structured so that all parts of the image fit together in a realistic and meaningful way. Yet, established image quality metrics do not explicitly quantify this property of synthetic images. In this work, we introduce two metrics that can measure the global consistency of synthetic images on a per-image basis. To measure the global consistency, we presume that a realistic image exhibits consistent properties, e.g., a person's body fat in a whole-body MRI, throughout the depicted object or scene. Hence, we quantify global consistency by predicting and comparing explicit attributes of images on patches using supervised trained neural networks. Next, we adapt this strategy to an unlabeled setting by measuring the similarity of implicit image features predicted by a self-supervised trained network. Our results demonstrate that predicting explicit attributes of synthetic images on patches can distinguish globally consistent from inconsistent images. Implicit representations of images are less sensitive to assess global consistency but are still serviceable when labeled data is unavailable. Compared to established metrics, such as the FID, our method can explicitly measure global consistency on a per-image basis, enabling a dedicated analysis of the biological plausibility of single synthetic images.

Abstract: The volume of space debris currently orbiting the Earth is reaching an unsustainable level at an accelerated pace. The detection, tracking, identification, and differentiation between orbit-defined, registered spacecraft, and rogue/inactive space ``objects'', is critical to asset protection. The primary objective of this work is to investigate the validity of Deep Neural Network (DNN) solutions to overcome the limitations and image artefacts most prevalent when captured with monocular cameras in the visible light spectrum. In this work, a hybrid UNet-ResNet34 Deep Learning (DL) architecture pre-trained on the ImageNet dataset, is developed. Image degradations addressed include blurring, exposure issues, poor contrast, and noise. The shortage of space-generated data suitable for supervised DL is also addressed. A visual comparison between the URes34P model developed in this work and the existing state of the art in deep learning image enhancement methods, relevant to images captured in space, is presented. Based upon visual inspection, it is determined that our UNet model is capable of correcting for space-related image degradations and merits further investigation to reduce its computational complexity.

Abstract: Contrast Enhanced Spectral Mammography (CESM) is a dual-energy mammographic imaging technique that first needs intravenously administration of an iodinated contrast medium; then, it collects bot a low-energy image, comparable to standard mammography, and a high-energy image. The two scans are then combined to get a recombined image showing contrast enhancement. Despite CESM diagnostic advantages for breast cancer diagnosis, the use of contrast medium can cause side effects, and CESM also beams patients with a higher radiation dose compared to standard mammography. To address these limitations this work proposes to use deep generative models for virtual contrast enhancement on CESM, aiming to make the CESM contrast-free as well as to reduce the radiation dose. Our deep networks, consisting of an autoencoder and two Generative Adversarial Networks, the Pix2Pix, and the CycleGAN, generate synthetic recombined images solely from low-energy images. We perform an extensive quantitative and qualitative analysis of the model's performance, also exploiting radiologists' assessments, on a novel CESM dataset that includes 1138 images that, as a further contribution of this work, we make publicly available. The results show that CycleGAN is the most promising deep network to generate synthetic recombined images, highlighting the potential of artificial intelligence techniques for virtual contrast enhancement in this field.

Abstract: The limited availability of labeled chest X-ray datasets is a significant bottleneck in the development of medical imaging methods. Self-supervised learning (SSL) can mitigate this problem by training models on unlabeled data. Furthermore, self-supervised pretraining has yielded promising results in visual recognition of natural images but has not been given much consideration in medical image analysis. In this work, we propose a self-supervised method, DINO-CXR, which is a novel adaptation of a self-supervised method, DINO, based on a vision transformer for chest X-ray classification. A comparative analysis is performed to show the effectiveness of the proposed method for both pneumonia and COVID-19 detection. Through a quantitative analysis, it is also shown that the proposed method outperforms state-of-the-art methods in terms of accuracy and achieves comparable results in terms of AUC and F-1 score while requiring significantly less labeled data.

Abstract: We propose an accurate and fast classification network for classification of brain tumors in MRI images that outperforms all lightweight methods investigated in terms of accuracy. We test our model on a challenging 2D T1-weighted CE-MRI dataset containing three types of brain tumors: Meningioma, Glioma and Pituitary. We introduce an l2-normalized spatial attention mechanism that acts as a regularizer against overfitting during training. We compare our results against the state-of-the-art on this dataset and show that by integrating l2-normalized spatial attention into a baseline network we achieve a performance gain of 1.79 percentage points. Even better accuracy can be attained by combining our model in an ensemble with the pretrained VGG16 at the expense of execution speed. Our code is publicly available at https://github.com/juliadietlmeier/MRI_image_classification

Abstract: This paper proposes a novel spatiotemporal (ST) fusion framework for satellite images, named Robust Optimization-based Spatiotemporal Fusion (ROSTF). ST fusion is a promising approach to resolve a trade-off between the temporal and spatial resolution of satellite images. Although many ST fusion methods have been proposed, most of them are not designed to explicitly account for noise in observed images, despite the inevitable influence of noise caused by the measurement equipment and environment. Our ROSTF addresses this challenge by treating the noise removal of the observed images and the estimation of the target high-resolution image as a single optimization problem. Specifically, first, we define observation models for satellite images possibly contaminated with random noise, outliers, and/or missing values, and then introduce certain assumptions that would naturally hold between the observed images and the target high-resolution image. Then, based on these models and assumptions, we formulate the fusion problem as a constrained optimization problem and develop an efficient algorithm based on a preconditioned primal-dual splitting method for solving the problem. The performance of ROSTF was verified using simulated and real data. The results show that ROSTF performs comparably to several state-of-the-art ST fusion methods in noiseless cases and outperforms them in noisy cases.

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer in which the tumor-vascular involvement greatly affects the resectability and, thus, overall survival of patients. However, current prognostic prediction methods fail to explicitly and accurately investigate relationships between the tumor and nearby important vessels. This paper proposes a novel learnable neural distance that describes the precise relationship between the tumor and vessels in CT images of different patients, adopting it as a major feature for prognosis prediction. Besides, different from existing models that used CNNs or LSTMs to exploit tumor enhancement patterns on dynamic contrast-enhanced CT imaging, we improved the extraction of dynamic tumor-related texture features in multi-phase contrast-enhanced CT by fusing local and global features using CNN and transformer modules, further enhancing the features extracted across multi-phase CT images. We extensively evaluated and compared the proposed method with existing methods in the multi-center (n=4) dataset with 1,070 patients with PDAC, and statistical analysis confirmed its clinical effectiveness in the external test set consisting of three centers. The developed risk marker was the strongest predictor of overall survival among preoperative factors and it has the potential to be combined with established clinical factors to select patients at higher risk who might benefit from neoadjuvant therapy.