Cancer Biology

AURKA inhibition amplifies DNA replication stress to foster WEE1 kinase dependency and synergistic antitumor effects with WEE1 inhibition in cancers

AURKA inhibition amplifies DNA replication str...

Cancer Biology
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Barbara Burtness
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eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small molecules

eIF3d and eIF3e mediate selective translationa...

Cancer Biology
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Rui Zhao
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Caspase-8 is a novel modulator of Homologous Recombination Repair in response to ionizing radiations

Caspase-8 is a novel modulator of Homologous R...

Cancer Biology
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librarian
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Preclinical Prediction of Resistance and Optimization of Sequential Therapy for ALK-positive Lung Cancer Using Next-generation ALK Inhibitors

Preclinical Prediction of Resistance and Optim...

Cancer Biology
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Kentaro Semba
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Multimodal gene and targeted drug therapy for chronic myelogenous leukemia: Computational target analysis and therapeutic validation

Multimodal gene and targeted drug therapy for ...

Cancer Biology
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Angela Fleischman
1 view
Notch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate Cancer

Notch as a Driver of Lineage Plasticity and Th...

Cancer Biology
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librarian
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The genomic and transcriptional landscape of the spinal cord H3K27-altered diffuse midline glioma suggests the potential therapeutic strategy

The genomic and transcriptional landscape of t...

Cancer Biology
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Wei Zhang
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The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice.

The penetrant chordoid glioma PRKCA mutation i...

Cancer Biology
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librarian
1 view
VCAN is essential for ERK5-driven tumorigenesis in soft tissue sarcoma

VCAN is essential for ERK5-driven tumorigenesi...

Cancer Biology
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Ricardo Sánchez Prieto
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Multiple FGFR1 mutations modulate tumorigenic mechanisms in glioneuronal tumors.

Multiple FGFR1 mutations modulate tumorigenic ...

Cancer Biology
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Barbara Rivera
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The H3K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer

The H3K36M oncohistone inhibits NSD2 to activa...

Cancer Biology
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David Feldser
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Repurposing statins in combination therapy for effective ablation of metastatic breast cancer

Repurposing statins in combination therapy for...

Cancer Biology
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librarian
0 views
Role of DEPDC1 in Glioblastoma Malignant Phenotype and Radiosensitivity

Role of DEPDC1 in Glioblastoma Malignant Pheno...

Cancer Biology
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librarian
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Sex Disparities in Gastric Cancer Tumor Mutation Burden and Gene Mutation Patterns

Sex Disparities in Gastric Cancer Tumor Mutati...

Cancer Biology
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Dorit Shweiki
1 view
Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer

Jagged1 regulates extracellular matrix deposit...

Cancer Biology
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librarian
1 view
β2-integrins as biomarkers in urothelial cancer

β2-integrins as biomarkers in urothelial cancer

Cancer Biology
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librarian
1 view
DeepEpitope: Leveraging Transformation-Based protein Embeddings for Accurate linear Cancer B-cell Epitope Identification

DeepEpitope: Leveraging Transformation-Based p...

Cancer Biology
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librarian
4 views
PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer

PACT suppresses PKR activation through dsRNA b...

Cancer Biology
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Kyle Cottrell
5 views
Isoform-Specific Gene Regulation by Progesterone Receptors Drives Divergent Phenotypes in Breast Cancer Cells

Isoform-Specific Gene Regulation by Progestero...

Cancer Biology
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librarian
6 views
Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer

Matrix structure and microenvironment dynamics...

Cancer Biology
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Frances Balkwill
7 views
Patient-Derived Three-Dimensional Lung Tumor Models to Evaluate Response to Immunotherapy

Patient-Derived Three-Dimensional Lung Tumor M...

Cancer Biology
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Kayla Goliwas
8 views
Determining preclinical safety of Aclarubicin in pediatric malignancies

Determining preclinical safety of Aclarubicin ...

Cancer Biology
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librarian
7 views
SMARCA4 is essential for early-stage tumor development but its loss promotes late-stage cancer progression in small-cell lung cancer

SMARCA4 is essential for early-stage tumor dev...

Cancer Biology
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Kwon-Sik Park
8 views
Therapy resistance in AML is mediated by cytoplasmic sequestration of the transcriptional repressor IRF2BP2

Therapy resistance in AML is mediated by cytop...

Cancer Biology
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librarian
7 views
PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes

PIWIL2 downregulation in colon cancer promotes...

Cancer Biology
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librarian
8 views
The epigenetic regulator TRIM24 controls melanoma cell dedifferentiation and resistance to treatment in melanoma

The epigenetic regulator TRIM24 controls melan...

Cancer Biology
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Julie Caramel
9 views
In silico drug sensitivity predicts subgroup-specific therapeutics in medulloblastoma patients

In silico drug sensitivity predicts subgroup-s...

Cancer Biology
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librarian
7 views
Integrative Multi-Omics Analysis Identifies Nuclear Factor I as a Key Driver of Dysregulated Purine Metabolism in DIPG

Integrative Multi-Omics Analysis Identifies Nu...

Cancer Biology
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librarian
15 views
The 1p/19q co-deletion induces targetable and imageable vulnerabilities in glucose metabolism in oligodendrogliomas

The 1p/19q co-deletion induces targetable and ...

Cancer Biology
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librarian
7 views
Optimisation of pembrolizumab therapy for de novo metastatic MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations

Optimisation of pembrolizumab therapy for de n...

Cancer Biology
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librarian
8 views
Predicting GD2 expression across cancer types by the integration of pathway topology and transcriptome data

Predicting GD2 expression across cancer types ...

Cancer Biology
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Arsenij Ustjanzew
6 views
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer

PLK1-mediated phosphorylation of PHGDH reprogr...

Cancer Biology
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librarian
7 views
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