The unreasonable effectiveness of the total quasi-steady state approximation, and its limitations
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The unreasonable effectiveness of the total quasi-steady state approximation, and its limitations
Eilertsen, J.; Schnell, S.; Walcher, S.
AbstractIn this short note, we investigate the applicability and clarify the role of the total quasi-steady-state approximation for the Michaelis-Menten reaction mechanism. We show that small initial reduced substrate concentration, s0/KM [->] 0, is the crucial criterion for validity.