Systems Biology

Network-scale disruption of RNA-protein interactions by a bioaccumulating small-molecule drug

Network-scale disruption of RNA-protein intera...

Systems Biology
Avatar
librarian
26 views
Kruppel-like factors KLF5 & KLF8 emerge as master transcriptional regulators of Alzheimers disease, as revealed on cell fate regulomes in human brain organoids

Kruppel-like factors KLF5 & KLF8 emerge as mas...

Systems Biology
Avatar
librarian
23 views
Single-cell foundation models predict durable CAR T response despite imperfect cell annotation

Single-cell foundation models predict durable ...

Systems Biology
Avatar
librarian
23 views
Morphomechanically-Informed Spatial Curvature Sequencing in Prostate Cancer

Morphomechanically-Informed Spatial Curvature ...

Systems Biology
Avatar
librarian
27 views
Regulatory Bias Constrains Epigenetic Aging Trajectories

Regulatory Bias Constrains Epigenetic Aging Tr...

Systems Biology
Avatar
Taisiia Morozova
26 views
Flux-species sampling enables holistic exploration of biocircuit behavior

Flux-species sampling enables holistic explora...

Systems Biology
Avatar
librarian
34 views
Rod pathway blockade improves visual function in a mouse model of photoreceptor degeneration

Rod pathway blockade improves visual function ...

Systems Biology
Avatar
Teresa Puthussery
31 views
Quantitative Description of C. elegans mRNA Landscapes From High Coverage Single Cell Transcriptomes

Quantitative Description of C. elegans mRNA La...

Systems Biology
Avatar
Denis Dupuy
36 views
ChatGEM: An Agentic Architecture Enabling Interactive Simulation of Genome-Scale Metabolic Models

ChatGEM: An Agentic Architecture Enabling Inte...

Systems Biology
Avatar
librarian
29 views
Dynamic knowledge representation of blood brain barrier activation, injury and restitution with a novel agent-based model

Dynamic knowledge representation of blood brai...

Systems Biology
Avatar
librarian
29 views
A hybrid machine learning and enzyme-constrained metabolic model for ab initio prediction of proteome reallocation

A hybrid machine learning and enzyme-constrain...

Systems Biology
Avatar
librarian
29 views
Diversity and evolution of the transcriptional regulatory networks of Pseudomonas strains revealed using machine learning

Diversity and evolution of the transcriptional...

Systems Biology
Avatar
librarian
32 views
Experimentally calibrated computational modeling of inflammation and vascular remodeling in breast cavity healing following breast-conserving surgery

Experimentally calibrated computational modeli...

Systems Biology
Avatar
librarian
38 views
Textural features for pathway-level representation of omics data in biological networks

Textural features for pathway-level representa...

Systems Biology
Avatar
librarian
37 views
Deep Visual Proteomics links vascular smooth muscle cell phenotypes to atherosclerotic plaque stability

Deep Visual Proteomics links vascular smooth m...

Systems Biology
Avatar
librarian
34 views
Coupled Cell-Intrinsic and Microenvironmental Heterogeneity Drives Divergent Trajectories in Castration-Resistant Prostate Cancer

Coupled Cell-Intrinsic and Microenvironmental ...

Systems Biology
Avatar
librarian
36 views
Predicting the protein interaction landscape of a mycobacterial pathogen

Predicting the protein interaction landscape o...

Systems Biology
Avatar
librarian
38 views
Large-scale, interpretable gene regulatory network inference through biologically informed matrix factorization

Large-scale, interpretable gene regulatory net...

Systems Biology
Avatar
librarian
37 views
Beta-adrenergic receptor activation during stress reduces the abundance of commensal Clostridia in the mouse gut

Beta-adrenergic receptor activation during str...

Systems Biology
Avatar
Brian Corbett
41 views
Axolotl regeneration reveals a dormant cis-regulatory grammar conserved across vertebrate genomes

Axolotl regeneration reveals a dormant cis-reg...

Systems Biology
Avatar
librarian
38 views
Gene Regulatory Networks that support Multi-Fate Cellular Decisions

Gene Regulatory Networks that support Multi-Fa...

Systems Biology
Avatar
librarian
36 views
Diversity in transcriptomics without cell types

Diversity in transcriptomics without cell types

Systems Biology
Avatar
Leyi Jiang
43 views
A Spatial Agent-Based Model of AGE-RAGE Feedback in Hepatic Fibrosis Reveals Stage-Dependent Irreversibility Thresholds

A Spatial Agent-Based Model of AGE-RAGE Feedba...

Systems Biology
Avatar
librarian
50 views
Large-scale analysis of optimisation methods for parameter estimation problems in the life sciences

Large-scale analysis of optimisation methods f...

Systems Biology
Avatar
librarian
40 views
A Bioengineered Live Biotherapeutic Exploits Inflammation to Restore Gut Liver Brain Axis Function under Diet-Induced Stress

A Bioengineered Live Biotherapeutic Exploits I...

Systems Biology
Avatar
Sanjoy Ghosh
37 views
Regulatory memory and growth-coupled inheritance shape nutrient-dependent flagella number variation in Salmonella

Regulatory memory and growth-coupled inheritan...

Systems Biology
Avatar
librarian
44 views
Metabolomic signatures support the diagnostics of peritoneal endometriosis using generalised linear models

Metabolomic signatures support the diagnostics...

Systems Biology
Avatar
Tea Lanišnik Rižner
46 views
HetNetEX: Exact Asymptotic Inference in Heterogeneous Biomedical Knowledge Graphs

HetNetEX: Exact Asymptotic Inference in Hetero...

Systems Biology
Avatar
librarian
39 views
How p53 stress memory could redirect JAK/STAT1 antiviral signalling: a model-based prediction.

How p53 stress memory could redirect JAK/STAT1...

Systems Biology
Avatar
librarian
47 views
Nutritional Anthelmintics: Chicory Reconfigures the Equine Holobiont Across Microbial, Parasitic, and Host Scales

Nutritional Anthelmintics: Chicory Reconfigure...

Systems Biology
Avatar
Núria Mach
38 views
Synthesizing Mechanistic Hypotheses from Single-Cell Omics via Discretized Feature Attribution and Empirical Language Model Grounding

Synthesizing Mechanistic Hypotheses from Singl...

Systems Biology
Avatar
Neil Lin
50 views
Kinome-wide CRISPR/Cas9-knockout screening reveals critical protein kinases in vasopressin V2-receptor signaling

Kinome-wide CRISPR/Cas9-knockout screening rev...

Systems Biology
Avatar
librarian
54 views
Load more