Systems Biology

Common cis-eQTLs do not explain chromosome 21 expression deviations from the ploidy expectation in Down syndrome

Common cis-eQTLs do not explain chromosome 21 ...

Systems Biology
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Lucas Gillenwater
4 views
Network-scale disruption of RNA-protein interactions by a bioaccumulating small-molecule drug

Network-scale disruption of RNA-protein intera...

Systems Biology
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librarian
182 views
Kruppel-like factors KLF5 & KLF8 emerge as master transcriptional regulators of Alzheimers disease, as revealed on cell fate regulomes in human brain organoids

Kruppel-like factors KLF5 & KLF8 emerge as mas...

Systems Biology
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librarian
163 views
Single-cell foundation models predict durable CAR T response despite imperfect cell annotation

Single-cell foundation models predict durable ...

Systems Biology
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librarian
160 views
Morphomechanically-Informed Spatial Curvature Sequencing in Prostate Cancer

Morphomechanically-Informed Spatial Curvature ...

Systems Biology
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librarian
179 views
Regulatory Bias Constrains Epigenetic Aging Trajectories

Regulatory Bias Constrains Epigenetic Aging Tr...

Systems Biology
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Taisiia Morozova
166 views
Flux-species sampling enables holistic exploration of biocircuit behavior

Flux-species sampling enables holistic explora...

Systems Biology
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librarian
170 views
Rod pathway blockade improves visual function in a mouse model of photoreceptor degeneration

Rod pathway blockade improves visual function ...

Systems Biology
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Teresa Puthussery
166 views
Quantitative Description of C. elegans mRNA Landscapes From High Coverage Single Cell Transcriptomes

Quantitative Description of C. elegans mRNA La...

Systems Biology
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Denis Dupuy
166 views
ChatGEM: An Agentic Architecture Enabling Interactive Simulation of Genome-Scale Metabolic Models

ChatGEM: An Agentic Architecture Enabling Inte...

Systems Biology
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librarian
160 views
Dynamic knowledge representation of blood brain barrier activation, injury and restitution with a novel agent-based model

Dynamic knowledge representation of blood brai...

Systems Biology
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librarian
166 views
A hybrid machine learning and enzyme-constrained metabolic model for ab initio prediction of proteome reallocation

A hybrid machine learning and enzyme-constrain...

Systems Biology
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librarian
149 views
Diversity and evolution of the transcriptional regulatory networks of Pseudomonas strains revealed using machine learning

Diversity and evolution of the transcriptional...

Systems Biology
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librarian
166 views
Experimentally calibrated computational modeling of inflammation and vascular remodeling in breast cavity healing following breast-conserving surgery

Experimentally calibrated computational modeli...

Systems Biology
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librarian
177 views
Textural features for pathway-level representation of omics data in biological networks

Textural features for pathway-level representa...

Systems Biology
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librarian
167 views
Deep Visual Proteomics links vascular smooth muscle cell phenotypes to atherosclerotic plaque stability

Deep Visual Proteomics links vascular smooth m...

Systems Biology
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librarian
187 views
Coupled Cell-Intrinsic and Microenvironmental Heterogeneity Drives Divergent Trajectories in Castration-Resistant Prostate Cancer

Coupled Cell-Intrinsic and Microenvironmental ...

Systems Biology
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librarian
174 views
Predicting the protein interaction landscape of a mycobacterial pathogen

Predicting the protein interaction landscape o...

Systems Biology
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librarian
169 views
Large-scale, interpretable gene regulatory network inference through biologically informed matrix factorization

Large-scale, interpretable gene regulatory net...

Systems Biology
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librarian
166 views
Beta-adrenergic receptor activation during stress reduces the abundance of commensal Clostridia in the mouse gut

Beta-adrenergic receptor activation during str...

Systems Biology
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Brian Corbett
181 views
Axolotl regeneration reveals a dormant cis-regulatory grammar conserved across vertebrate genomes

Axolotl regeneration reveals a dormant cis-reg...

Systems Biology
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librarian
161 views
Gene Regulatory Networks that support Multi-Fate Cellular Decisions

Gene Regulatory Networks that support Multi-Fa...

Systems Biology
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librarian
154 views
Diversity in transcriptomics without cell types

Diversity in transcriptomics without cell types

Systems Biology
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Leyi Jiang
174 views
A Spatial Agent-Based Model of AGE-RAGE Feedback in Hepatic Fibrosis Reveals Stage-Dependent Irreversibility Thresholds

A Spatial Agent-Based Model of AGE-RAGE Feedba...

Systems Biology
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librarian
185 views
Large-scale analysis of optimisation methods for parameter estimation problems in the life sciences

Large-scale analysis of optimisation methods f...

Systems Biology
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librarian
171 views
A Bioengineered Live Biotherapeutic Exploits Inflammation to Restore Gut Liver Brain Axis Function under Diet-Induced Stress

A Bioengineered Live Biotherapeutic Exploits I...

Systems Biology
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Sanjoy Ghosh
167 views
Regulatory memory and growth-coupled inheritance shape nutrient-dependent flagella number variation in Salmonella

Regulatory memory and growth-coupled inheritan...

Systems Biology
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librarian
172 views
Metabolomic signatures support the diagnostics of peritoneal endometriosis using generalised linear models

Metabolomic signatures support the diagnostics...

Systems Biology
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Tea Lanišnik Rižner
169 views
HetNetEX: Exact Asymptotic Inference in Heterogeneous Biomedical Knowledge Graphs

HetNetEX: Exact Asymptotic Inference in Hetero...

Systems Biology
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librarian
164 views
How p53 stress memory could redirect JAK/STAT1 antiviral signalling: a model-based prediction.

How p53 stress memory could redirect JAK/STAT1...

Systems Biology
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librarian
181 views
Nutritional Anthelmintics: Chicory Reconfigures the Equine Holobiont Across Microbial, Parasitic, and Host Scales

Nutritional Anthelmintics: Chicory Reconfigure...

Systems Biology
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Núria Mach
159 views
Synthesizing Mechanistic Hypotheses from Single-Cell Omics via Discretized Feature Attribution and Empirical Language Model Grounding

Synthesizing Mechanistic Hypotheses from Singl...

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Neil Lin
172 views
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