Lang, B.; Babu, M. M.

Synchronizing protein structure predictions with sequence databases is crucial for their accuracy. We developed AlphaSync (https://alphasync.stjude.org), a pipeline and database that provides updated AlphaFold structure models for currently 26,797 UniProt proteins, including isoforms. Moreover, AlphaSync enhances 2.6 million structures with residue-level features, including solvent accessibility, dihedral angles, intrinsic disorder predictions, and 4.7 billion atom-level noncovalent contacts. AlphaSync\'s user-friendly interface enables structural analyses at scale across up-to-date proteomes for 41 species.