Goebel, A. M.; Zhou, S.; Wang, Z.; Tzourtzou, S.; Himmelbach, A.; Zheng, S.; Pradillo, M.; Liu, C.; JIANG, H.

One key structural element in the three-dimensional (3D) chromatin organization is the Topologically Associating Domain (TAD), which facilitates the formation of distinct chromatin compartments and fosters specific chromatin interactions. Similar chromatin compartments, known as TAD-like domains, have been identified in many plant species. However, the model plant Arabidopsis thaliana has been an exception. In this study, we address this long-standing issue by presenting evidence that Arabidopsis PDS5 proteins play a crucial role in preventing the formation of TAD-like domains.