Di Sano, C.; D'Anna, C.; Li Petri, G.; Angellotti, G.; Meneguzzo, F.; Pagliaro, M.; Ciriminna, R.

Citrus IntegroPectin bioconjugates obtained through acoustic cavitation in water of different citrus fruit (lemon, red orange, and sweet orange) processing waste show substantial anticancer activity in vitro against human non-small cell lung cancer cells. Dis-solved in aqueous phase at different concentrations, all IntegroPectin phytocomplexes tested affected long-term proliferation and cell migration of adeno-carcinoma cells of line A549. Compared to sweet orange, IntegroPectin from lemon and red orange were more effective in reducing colony formation activity. Pointing to significant reduction in cancer cell progression, these results support further inves-tigation of these new low methoxyl pectins rich in citrus flavonoids and RG-I regions for the treatment of lung cancer.