Pharmacology and Toxicology

Acute Toxicological Profile of Pharmaceutical-Grade Nicotinamide Riboside: A Route-Dependent Assessment Across Intravenous, Intramuscular, and Subcutaneous Administration

Acute Toxicological Profile of Pharmaceutical-...

Pharmacology and Toxicology
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Jun Kwon
3 views
Tetracycline-Regulated Inducible CB2 Expression in AtT20 Cells: A Functional Assay for Quantifying Ligand Efficacy

Tetracycline-Regulated Inducible CB2 Expressio...

Pharmacology and Toxicology
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Mark Connor
6 views
vToxiNet: a biologically constrained deep learning framework for interpretable prediction of drug-induced hepatotoxicity

vToxiNet: a biologically constrained deep lear...

Pharmacology and Toxicology
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Hao Zhu
4 views
Short-Term Performance Assay Identifies Functional Benefits and Early Toxicity of Longevity Interventions in Mice

Short-Term Performance Assay Identifies Functi...

Pharmacology and Toxicology
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Alberto Parras
17 views
Suppressing Bone Resorption and Promoting Mineralization with Tetracycline Derivatives

Suppressing Bone Resorption and Promoting Mine...

Pharmacology and Toxicology
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librarian
12 views
A Degron Decoy System Co-opts Pathological Seeding to Enable Clearance of Multimeric α-Synuclein.

A Degron Decoy System Co-opts Pathological See...

Pharmacology and Toxicology
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librarian
8 views
Single-cell transcriptomics reveals a differential response of human bronchial epithelial cell-types to cadmium chloride

Single-cell transcriptomics reveals a differen...

Pharmacology and Toxicology
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librarian
26 views
Oxytocin treats respiratory depression and reduces mortality from fentanyl and the combination of xylazine-fentanyl

Oxytocin treats respiratory depression and red...

Pharmacology and Toxicology
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David Mendelowitz
10 views
Gene III Ergothioneine Ameliorates Exercise-Induced Fatigue by Attenuating Oxidative Stress, Inflammation, and Modulating the AMPK/PGC-1α Signaling Pathway

Gene III Ergothioneine Ameliorates Exercise-In...

Pharmacology and Toxicology
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librarian
9 views
Transcriptomic data of larval zebrafish exposed to continuous sub- and supra-MCL sodium arsenite and uranyl nitrate.

Transcriptomic data of larval zebrafish expose...

Pharmacology and Toxicology
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librarian
7 views
Gene III Ergothioneine ameliorates alcoholic fatty liver disease: A dual strategy of accelerated ethanol elimination and reducing oxidative stress

Gene III Ergothioneine ameliorates alcoholic f...

Pharmacology and Toxicology
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Guohua Xiao
11 views
PFOA induced metabolic and immune perturbations in a SARS-2 infection model

PFOA induced metabolic and immune perturbation...

Pharmacology and Toxicology
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librarian
11 views
Discovery and Optimization of Small Molecule Inhibitors of the SLIT2/ROBO1 Protein-Protein Interaction Using DNA-Encoded Libraries

Discovery and Optimization of Small Molecule I...

Pharmacology and Toxicology
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librarian
13 views
A metabolically resistant spexin analogue, LIT-01-144, induces potent non-opioid peripheral antinociception in persistent pain via activation of GALR2

A metabolically resistant spexin analogue, LIT...

Pharmacology and Toxicology
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Dominique Bonnet
12 views
Wildfire emitted particulate matter induces ovarian hyperandrogenism through aryl hydrocarbon receptor activation

Wildfire emitted particulate matter induces ov...

Pharmacology and Toxicology
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librarian
11 views
Diet modulates metabolic and hepatic responses to chronic pesticide mixture exposure in mice

Diet modulates metabolic and hepatic responses...

Pharmacology and Toxicology
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Laurence Gamet-Payrastre
13 views
Novel Plasma Proteomics and Phosphoproteomics Platform Captures Pleiotropic Cardiometabolic Spectrum Effects of Semaglutide in Patients with T2D and Atherosclerosis: A Companion Diagnostic Pilot Study from the STOP (Semaglutide Treatment On coronary atherosclerosis Progression) Randomized Trial

Novel Plasma Proteomics and Phosphoproteomics ...

Pharmacology and Toxicology
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librarian
9 views
Identification of a pharmacokinetic interaction between teicoplanin and sulfo-butyl ether-β-cyclodextrin, an excipient in the intravenous posaconazole formulation

Identification of a pharmacokinetic interactio...

Pharmacology and Toxicology
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Shunsaku Nakagawa
11 views
DRP1 inhibition confers cardioprotection against doxorubicin while preserving anticancer efficacy

DRP1 inhibition confers cardioprotection again...

Pharmacology and Toxicology
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librarian
12 views
A novel pharmacogenetic testing panel for CYP2C19 genetic polymorphisms

A novel pharmacogenetic testing panel for CYP2...

Pharmacology and Toxicology
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Miracle Enwere
18 views
Brahmi Ghrita Exerts Nephroprotective Effects by Restoring Cytoskeletal Integrity and Ion Transport in Drosophila Model of Polycystic Kidney Disease

Brahmi Ghrita Exerts Nephroprotective Effects ...

Pharmacology and Toxicology
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Madhu Tapadia
12 views
Mitigating CYP450-Mediated Insecticide Resistance in Malaria Vectors with Cannabis-Derived Synergists: The Potential of Cannabidiol

Mitigating CYP450-Mediated Insecticide Resista...

Pharmacology and Toxicology
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librarian
14 views
Conserved Molecular Responses to Arsenite Exposure in Drosophila melanogaster

Conserved Molecular Responses to Arsenite Expo...

Pharmacology and Toxicology
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librarian
20 views
OKN4395, a first-in-class EP2/EP4/DP1 triple antagonist reprograms prostanoid-driven immunosuppression to restore antitumor immunity

OKN4395, a first-in-class EP2/EP4/DP1 triple a...

Pharmacology and Toxicology
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librarian
21 views
ToxMCP: Guardrailed, Auditable Agentic Workflows for Computational Toxicology via the Model Context Protocol

ToxMCP: Guardrailed, Auditable Agentic Workflo...

Pharmacology and Toxicology
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librarian
42 views
Predicting Sex-Specific Antiarrhythmic Strategies for Atrial Fibrillation through a Regression-Guided Computational Modeling Pipeline

Predicting Sex-Specific Antiarrhythmic Strateg...

Pharmacology and Toxicology
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Eleonora Grandi
30 views
Cellular thermal shift assay of subcellular isolates for evaluating drug-membrane target interactions

Cellular thermal shift assay of subcellular is...

Pharmacology and Toxicology
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librarian
24 views
Exploiting NMR Ensemble Heterogeneity Enables Small Molecule Discovery Against Dynamic Protein-Protein Interfaces

Exploiting NMR Ensemble Heterogeneity Enables ...

Pharmacology and Toxicology
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librarian
20 views
Model-Driven Hybrid AI Framework for End-to-End Autonomous Decision-Making in Drug Development

Model-Driven Hybrid AI Framework for End-to-En...

Pharmacology and Toxicology
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librarian
19 views
Model Ensembling and Machine Learning Approaches to Predict the First Dose of Amoxicillin in Intensive Care

Model Ensembling and Machine Learning Approach...

Pharmacology and Toxicology
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librarian
20 views
Visual - Acoustic Thigmotaxis in Zebrafish Larvae: A High throughput NAM for Neurotoxicity Assessment

Visual - Acoustic Thigmotaxis in Zebrafish Lar...

Pharmacology and Toxicology
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Monica Torres-Ruiz
30 views
Predicting early bactericidal activity of tuberculosis drug combinations using a translational pharmacokinetic-pharmacodynamic modeling approach

Predicting early bactericidal activity of tube...

Pharmacology and Toxicology
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librarian
24 views
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