Pharmacology and Toxicology

Discovery of a brain-penetrant CHI3L1 inhibitor as an oral modulator of neuroinflammation in Alzheimers disease

Discovery of a brain-penetrant CHI3L1 inhibito...

Pharmacology and Toxicology
Avatar
librarian
33 views
Characterization of Cytochrome P450-Mediated Metabolism of Δ8-tetrahydrocannabinol in vitro

Characterization of Cytochrome P450-Mediated M...

Pharmacology and Toxicology
Avatar
librarian
23 views
DNA-Encoded Library-Guided Discovery of a First-in-Class Molecular Glue of the NOS1AP-SCRIB Complex in Alzheimer's Disease Patient-Derived Neurons

DNA-Encoded Library-Guided Discovery of a Firs...

Pharmacology and Toxicology
Avatar
Moustafa Gabr
39 views
A Multiplex Protein Microarray Platform for Preclinical Tissue Binding and Cross-Reactivity of Therapeutic Antibodies

A Multiplex Protein Microarray Platform for Pr...

Pharmacology and Toxicology
Avatar
librarian
39 views
Green synthesis of silver nanoparticles from Artemisia afra and Artemisia annua leaf extracts: Enhanced in vitro anthelmintic activity against Haemonchus contortus

Green synthesis of silver nanoparticles from A...

Pharmacology and Toxicology
Avatar
librarian
31 views
6-Methylnicotine is a strong agonist at α4β2 and α3β4 nicotinic cholinergic receptors

6-Methylnicotine is a strong agonist at α4β2 a...

Pharmacology and Toxicology
Avatar
Kenneth Kellar
32 views
Microglia transcriptomic response to doxorubicin-induced genotoxic stress

Microglia transcriptomic response to doxorubic...

Pharmacology and Toxicology
Avatar
librarian
67 views
Rank-Resolved Multi-Engine Docking and Optuna-Optimized Re-Ranking with ProDock for Virtual Screening

Rank-Resolved Multi-Engine Docking and Optuna-...

Pharmacology and Toxicology
Avatar
Lai Hoang Son Le
192 views
A non-invasive method of air pollutant exposure in an avian model of development

A non-invasive method of air pollutant exposur...

Pharmacology and Toxicology
Avatar
librarian
180 views
An Insectified Caco-2 Cell-Based assay to monitor pesticide Transport Processes and Pharmacokinetics

An Insectified Caco-2 Cell-Based assay to moni...

Pharmacology and Toxicology
Avatar
Kassiani Skouloudaki
190 views
Estimating Cardiac 5-HT2B Safety Margins for Repeated Low-Dose Psilocybin Using an Exposure-Response Model

Estimating Cardiac 5-HT2B Safety Margins for R...

Pharmacology and Toxicology
Avatar
librarian
168 views
Dronedarone hydrochloride reverses obesity-related metabolic syndrome while preserving skeletal muscle mass

Dronedarone hydrochloride reverses obesity-rel...

Pharmacology and Toxicology
Avatar
librarian
163 views
GEM-GPT Enables Personalized Cell Type-Resolved Therapeutic Design for Systems Pharmacology

GEM-GPT Enables Personalized Cell Type-Resolve...

Pharmacology and Toxicology
Avatar
librarian
163 views
Endocannabinoid ligands (CBD, Δ9THC, and Terpenes) inhibit excitability of mouse dorsal root ganglion neurons and exhibit synergistic inhibitory effects

Endocannabinoid ligands (CBD, Δ9THC, and Terpe...

Pharmacology and Toxicology
Avatar
librarian
175 views
Endothelial β3-Adrenergic Receptor activation prevents pulmonary hypertension

Endothelial β3-Adrenergic Receptor activation ...

Pharmacology and Toxicology
Avatar
Eduardo Oliver
187 views
Patolakaturohiniyadi Kashayam, exerts anti-steatotic and anti-obesogenic effects via coordinated regulation of lipid metabolism, inflammation, and incretin signalling.

Patolakaturohiniyadi Kashayam, exerts anti-ste...

Pharmacology and Toxicology
Avatar
Sania Kouser
189 views
Species-dependent clearance of alternariol monomethyl ether, tenuazonic acid and altertoxin II in rat and human primary hepatocytes

Species-dependent clearance of alternariol mon...

Pharmacology and Toxicology
Avatar
Ludovic Lehegarat
190 views
Human-Relevant Lead Exposure During Differentiation Alters the Transcriptomic Profile of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Human-Relevant Lead Exposure During Differenti...

Pharmacology and Toxicology
Avatar
librarian
172 views
An aptamer targeting TfR1 enhances ASO delivery to muscle tissue

An aptamer targeting TfR1 enhances ASO deliver...

Pharmacology and Toxicology
Avatar
librarian
183 views
Binding to Albumin and Off-Target Toxicity Confound the Use of LRRC8/VRAC Channel Blockers in Cell Physiology Assays

Binding to Albumin and Off-Target Toxicity Con...

Pharmacology and Toxicology
Avatar
Alexander Mongin
190 views
Multiscale learning and topological analysis across complex postures enable robust nematode size quantification in pharmacological assays

Multiscale learning and topological analysis a...

Pharmacology and Toxicology
Avatar
librarian
181 views
Perinatal exposure to individual and a metal mixture induces persistent and sex-specific alterations to the cardiac transcriptome of offspring

Perinatal exposure to individual and a metal m...

Pharmacology and Toxicology
Avatar
librarian
162 views
Phosphocitrate Is Superior to Pyrophosphate in Preventing Soft Connective Tissue Calcification in a Mouse Model of Pseudoxanthoma Elasticum

Phosphocitrate Is Superior to Pyrophosphate in...

Pharmacology and Toxicology
Avatar
Koen van de Wetering
179 views
The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation

The Nematicide Tioxazafen Disrupts Proteasome ...

Pharmacology and Toxicology
Avatar
Peter Roy
170 views
Modulation of the agonist and antagonist activity of peptidic FPR1 ligands through N-terminal modifications: A structural and functional analysis

Modulation of the agonist and antagonist activ...

Pharmacology and Toxicology
Avatar
librarian
164 views
Increases in serum corticosterone level and diuresis induced by the selective kappa opioid receptor (KOR) agonist U50,488H are unaffected by KOR phosphorylation

Increases in serum corticosterone level and di...

Pharmacology and Toxicology
Avatar
librarian
176 views
Multi-Modal Toxicological Evaluation of NiO nanoparticles and ionic nickel in a Human Lung-Cardiac Co-Culture System

Multi-Modal Toxicological Evaluation of NiO na...

Pharmacology and Toxicology
Avatar
librarian
182 views
From exact gradients to exact standard errors: third-order sensitivity equations for the FOCE and FOCEI population likelihood

From exact gradients to exact standard errors:...

Pharmacology and Toxicology
Avatar
librarian
184 views
Effect of Immunosuppressive Drugs on Glucose-Stimulated Insulin Secretion: Concentration-Response Studies in Dynamic Perifusion Assays

Effect of Immunosuppressive Drugs on Glucose-S...

Pharmacology and Toxicology
Avatar
librarian
173 views
Allosteric modulation of β1 integrin through the hybrid domain reverses articular cartilage injury and functional impairment in a murine model of inflammatory arthritis

Allosteric modulation of β1 integrin through t...

Pharmacology and Toxicology
Avatar
librarian
189 views
Comprehensive dissection of GPCR signaling using a NanoBiT-based platform

Comprehensive dissection of GPCR signaling usi...

Pharmacology and Toxicology
Avatar
librarian
181 views
In vitro EAS-mediated activity of Alternaria toxins

In vitro EAS-mediated activity of Alternaria t...

Pharmacology and Toxicology
Avatar
librarian
174 views
Load more