Pharmacology and Toxicology

Endothelial β3-Adrenergic Receptor activation prevents pulmonary hypertension

Endothelial β3-Adrenergic Receptor activation ...

Pharmacology and Toxicology
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Eduardo Oliver
4 views
Patolakaturohiniyadi Kashayam, exerts anti-steatotic and anti-obesogenic effects via coordinated regulation of lipid metabolism, inflammation, and incretin signalling.

Patolakaturohiniyadi Kashayam, exerts anti-ste...

Pharmacology and Toxicology
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Sania Kouser
3 views
Species-dependent clearance of alternariol monomethyl ether, tenuazonic acid and altertoxin II in rat and human primary hepatocytes

Species-dependent clearance of alternariol mon...

Pharmacology and Toxicology
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Ludovic Lehegarat
4 views
Human-Relevant Lead Exposure During Differentiation Alters the Transcriptomic Profile of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Human-Relevant Lead Exposure During Differenti...

Pharmacology and Toxicology
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librarian
6 views
An aptamer targeting TfR1 enhances ASO delivery to muscle tissue

An aptamer targeting TfR1 enhances ASO deliver...

Pharmacology and Toxicology
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librarian
9 views
Binding to Albumin and Off-Target Toxicity Confound the Use of LRRC8/VRAC Channel Blockers in Cell Physiology Assays

Binding to Albumin and Off-Target Toxicity Con...

Pharmacology and Toxicology
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Alexander Mongin
11 views
Multiscale learning and topological analysis across complex postures enable robust nematode size quantification in pharmacological assays

Multiscale learning and topological analysis a...

Pharmacology and Toxicology
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librarian
10 views
Perinatal exposure to individual and a metal mixture induces persistent and sex-specific alterations to the cardiac transcriptome of offspring

Perinatal exposure to individual and a metal m...

Pharmacology and Toxicology
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librarian
4 views
Phosphocitrate Is Superior to Pyrophosphate in Preventing Soft Connective Tissue Calcification in a Mouse Model of Pseudoxanthoma Elasticum

Phosphocitrate Is Superior to Pyrophosphate in...

Pharmacology and Toxicology
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Koen van de Wetering
10 views
The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation

The Nematicide Tioxazafen Disrupts Proteasome ...

Pharmacology and Toxicology
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Peter Roy
10 views
Modulation of the agonist and antagonist activity of peptidic FPR1 ligands through N-terminal modifications: A structural and functional analysis

Modulation of the agonist and antagonist activ...

Pharmacology and Toxicology
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librarian
8 views
Increases in serum corticosterone level and diuresis induced by the selective kappa opioid receptor (KOR) agonist U50,488H are unaffected by KOR phosphorylation

Increases in serum corticosterone level and di...

Pharmacology and Toxicology
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librarian
12 views
Multi-Modal Toxicological Evaluation of NiO nanoparticles and ionic nickel in a Human Lung-Cardiac Co-Culture System

Multi-Modal Toxicological Evaluation of NiO na...

Pharmacology and Toxicology
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librarian
9 views
From exact gradients to exact standard errors: third-order sensitivity equations for the FOCE and FOCEI population likelihood

From exact gradients to exact standard errors:...

Pharmacology and Toxicology
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librarian
8 views
Effect of Immunosuppressive Drugs on Glucose-Stimulated Insulin Secretion: Concentration-Response Studies in Dynamic Perifusion Assays

Effect of Immunosuppressive Drugs on Glucose-S...

Pharmacology and Toxicology
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librarian
17 views
Allosteric modulation of β1 integrin through the hybrid domain reverses articular cartilage injury and functional impairment in a murine model of inflammatory arthritis

Allosteric modulation of β1 integrin through t...

Pharmacology and Toxicology
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librarian
20 views
Comprehensive dissection of GPCR signaling using a NanoBiT-based platform

Comprehensive dissection of GPCR signaling usi...

Pharmacology and Toxicology
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librarian
15 views
In vitro EAS-mediated activity of Alternaria toxins

In vitro EAS-mediated activity of Alternaria t...

Pharmacology and Toxicology
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librarian
14 views
AlfaDAX-Derived ActRIIA/B Antibody with Semaglutide Enhances Fat Loss and Improves Weight-Loss Quality in DIO Mice

AlfaDAX-Derived ActRIIA/B Antibody with Semagl...

Pharmacology and Toxicology
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Kingsley Leung
13 views
Hazard characterization of Alternaria toxins - filling data gaps on in vitro genotoxicity.

Hazard characterization of Alternaria toxins -...

Pharmacology and Toxicology
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Anne-Cathrin Behr
13 views
Netrin-1 inhibition does not attenuate cancer-induced bone pain in three translational models

Netrin-1 inhibition does not attenuate cancer-...

Pharmacology and Toxicology
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librarian
15 views
The D2-mdx mouse as a preclinical model for Duchenne muscular dystrophy: a natural history study across two independent sites

The D2-mdx mouse as a preclinical model for Du...

Pharmacology and Toxicology
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librarian
19 views
Cytotoxicity of Pelargonic Acid and Its Commercial Formulation Roundup NL (Glyphosate-Free Roundup)

Cytotoxicity of Pelargonic Acid and Its Commer...

Pharmacology and Toxicology
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Michael Antoniou
23 views
Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological Systems

Voclosporin Preserves Mitochondrial Function C...

Pharmacology and Toxicology
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Edward Kelly
37 views
Mechanistic characterization of tenuazonic acid-induced cellular stress responses in human esophageal KYSE-510 cells

Mechanistic characterization of tenuazonic aci...

Pharmacology and Toxicology
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Dino Grgic
10 views
DSPE-PEG does not retain targeting antibodies on LNP surfaces in vivo; a higher molecular weight anchor is required

DSPE-PEG does not retain targeting antibodies ...

Pharmacology and Toxicology
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librarian
13 views
Green-synthesized silver nanoparticles enhance Guibourtia tessmannii antithromboinflammatory therapeutic potential

Green-synthesized silver nanoparticles enhance...

Pharmacology and Toxicology
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librarian
27 views
Novel apoptosis signal-regulating kinase 1 (ASK1) inhibitor SRT-015: Potential therapeutic for multiple liver diseases

Novel apoptosis signal-regulating kinase 1 (AS...

Pharmacology and Toxicology
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Kathleen Elias
29 views
β-alanine betaine and nAChRs in Ascaris

β-alanine betaine and nAChRs in Ascaris

Pharmacology and Toxicology
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librarian
21 views
The effects of estrogen exposure on survival, growth, and fecundity of Daphnia magna

The effects of estrogen exposure on survival, ...

Pharmacology and Toxicology
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S Schaack
34 views
Basal Internalization and Subcellular Localization of XCR1

Basal Internalization and Subcellular Localiza...

Pharmacology and Toxicology
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Fernando Salgado-Polo
27 views
Enhanced TRPV1 activation through TLR-4 and PKA signaling in Dorsal Root Ganglia Neurons

Enhanced TRPV1 activation through TLR-4 and PK...

Pharmacology and Toxicology
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librarian
42 views
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