Pharmacology and Toxicology

Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms
Avatar
librarian
0 views
Advanced Cardiac Organoid Model for Studying Doxorubicin-Induced Cardiotoxicity
Avatar
Xian Wu
1 view
High-Throughput Evaluation of Cryoprotective Agents for Mixture Effects That Reduce Toxicity
Avatar
librarian
1 view
Evaluation of the Basis and Performance of Simple Allometry for Predictions of Clearance and Oral Clearance in Humans and Improvement Potential with Added In Silico Predictions
Avatar
librarian
0 views
Anti-Sense Oligonucleotide as a Therapeutic for Synucleinopathies: Pharmacokinetic, Safety and Efficacy Evaluation
Avatar
librarian
1 view
Hybrid Population PK-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease
Avatar
librarian
1 view
Consumption of clinically relevant cannabidiol doses during pregnancy alters postnatal behavior in offspring
Avatar
librarian
2 views
Single-Shot Design of a Cyclic Peptide Inhibitor of HIV-1 Membrane Fusion with EvoBind
Avatar
librarian
9 views
Development and Validation of a Stem Cell-Based Kidney Organoid Platform for Nephrotoxicity Assessment
Avatar
librarian
3 views
Profiling of HCAR1 signaling reveals Gαi/o and Gαs activation without β-arrestin recruitment and the discovery of an allosteric agonist
Avatar
librarian
0 views
Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis
Avatar
Anne Ashford
2 views
Early-life PBDE flame retardant exposures cause neurobehavioral alterations in fish that persist into adulthood and vary by sex and route of exposure
Avatar
librarian
6 views
PBDE flame retardant exposure causes neurobehavioral and transcriptional effects in first-generation but not second-generation offspring fish
Avatar
Andrew Whitehead
5 views
SynVerse: A Framework for Systematic Evaluation of Deep Learning Based Drug Synergy Prediction Models
Avatar
librarian
4 views
GenVS TBDB: An Open AI-Generated andVirtual Screened Small-Molecule Database for Tuberculosis Drug Discovery
Avatar
librarian
3 views
Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis
Avatar
Grant Glatfelter
4 views
Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorder
Avatar
Fulton Crews
9 views
Nanotechnology-Driven Synergy: Research Effects of Curcumin Nanosuspension and Fluconazole Combination in Overcoming Azole Resistance in Candida Albicans
Avatar
Cheng Zhang
6 views
Exploring Phage-Staphylococcus aureus Host Dynamics Through Innovative In Vitro Experiment and Pharmacokinetic/pharmacodynamic Modeling
Avatar
librarian
6 views
RSPO2-based peptibodies conjugated with pyrrolobenzodiazepine dimer or camptothecin analogs demonstrate potent anti-tumor activity by targeting the three receptors LGR4/5/6
Avatar
librarian
6 views
An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity
Avatar
librarian
3 views
Cannabidiol Reduces Oxycodone Self-Administration While Preserving Its Analgesic Efficacy in a Rat Model of Neuropathic Pain
Avatar
librarian
12 views
On-cell Saturation Transfer Difference (STD) NMR on ion channels: characterizing negative allosteric modulator binding interactions of P2X7.
Avatar
Serena Monaco
11 views
G protein-coupled receptor 35 (GPR35) stimulation reduces osteoclast activity in primary human bone cells
Avatar
librarian
12 views
Peptide-functionalized fluorescent polymeric nanoparticles: polysarcosine length defines stealth properties
Avatar
librarian
7 views
Exploring Effective Ingredients and Potential Mechanisms of Stem Cell-derived Dendrobium Officinale Extract in Treatment of Allergic Rhinitis
Avatar
librarian
8 views
A Lipid Prodrug Strategy Enhances Targeted Protein Degrader CNS Pharmacokinetics
Avatar
librarian
8 views
Exploring the mechanism of kaji-ichigoside F1 on bacterial pneumonia based on the network pharmacology and transcriptome
Avatar
librarian
9 views
Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor
Avatar
librarian
12 views
Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay
Avatar
librarian
9 views
Evaluation of cytotoxic effects of diverse essential oils on human keratinocytes (HaCaT)
Avatar
librarian
11 views
CERIUM OXIDE NANOPARTICLES ATTENUATE THE PRO-ARRHYTHMIC EFFECT OF DIESEL EXHAUST PARTICLES IN ISOLATED RAT HEARTS BY REDUCING OXIDATIVE STRESS.
Avatar
Antonio Rodríguez-Sinovas
16 views