Pharmacology and Toxicology

Validation of a high-throughput screening assay for the characterization of cryoprotective agent toxicity

Validation of a high-throughput screening assa...

Pharmacology and Toxicology
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Rebecca Sandlin
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Discovery and Development of DC-174 as a Novel Oral Snakebite Treatment

Discovery and Development of DC-174 as a Novel...

Pharmacology and Toxicology
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librarian
2 views
In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely-moving behavior

In-dwelling microfluidic device for precise an...

Pharmacology and Toxicology
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librarian
0 views
TRPV4 activation enhances LPS-induced IL10 production to suppress excessive microglial activation

TRPV4 activation enhances LPS-induced IL10 pro...

Pharmacology and Toxicology
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librarian
0 views
Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

Mechanism of SK2 channel gating and its modula...

Pharmacology and Toxicology
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librarian
2 views
Neurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres

Neurotoxicity of Propylene Glycol Butyl Ether:...

Pharmacology and Toxicology
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Marie-Gabrielle Zurich
2 views
Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension

Endothelial c-IAP2 Loss Amplifies P2X7 Recepto...

Pharmacology and Toxicology
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Suellen Oliveira
2 views
Identification of antibody-drug conjugate payloads which are substrates of ATP-binding cassette drug efflux transporters

Identification of antibody-drug conjugate payl...

Pharmacology and Toxicology
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Matthew Hall
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Identification of new KCNT1-epilepsy drugs by in silico, cell and Drosophila modelling.

Identification of new KCNT1-epilepsy drugs by ...

Pharmacology and Toxicology
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Jonathan Lippiat
7 views
Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying Drug

Intranasal Dantrolene Nanoparticles for Treatm...

Pharmacology and Toxicology
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librarian
3 views
Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta

Bisdemethoxycurcumin mitigates Alzheimer disea...

Pharmacology and Toxicology
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Ajay Kumar
8 views
Evaluating the efficacy of LUMPY-NIL herbal powder, dermal Spray and dermal ointment in treating Lumpy Skin Disease (LSD) in Bovines

Evaluating the efficacy of LUMPY-NIL herbal po...

Pharmacology and Toxicology
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librarian
6 views
RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription

RAC1 Regulates Shh-Medulloblastoma Growth via ...

Pharmacology and Toxicology
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librarian
5 views
Alcohol Disrupts Neural Differentiation Through Endoplasmic Reticulum Stress and PERK Pathway Activation

Alcohol Disrupts Neural Differentiation Throug...

Pharmacology and Toxicology
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librarian
9 views
Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats

Mitragynine and 7-Hydroxymitragynine: Bidirect...

Pharmacology and Toxicology
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Samuel Obeng
7 views
Differential responses of murine embryonic stem cells (mESC) and their endothelial progeny to doxorubicin and pharmacological inhibitors of DNA repair and DNA damage response

Differential responses of murine embryonic ste...

Pharmacology and Toxicology
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librarian
8 views
The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels

The sodium/glucose cotransporter 2 inhibitor e...

Pharmacology and Toxicology
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Karlheinz Hilber
13 views
CHI3L1-Targeted Small Molecules as Glioblastoma Therapies: Virtual Screening-Based Discovery, Biophysical Validation, Pharmacokinetic Profiling, and Evaluation in Glioblastoma Spheroids

CHI3L1-Targeted Small Molecules as Glioblastom...

Pharmacology and Toxicology
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librarian
13 views
Promising protocol for in vivo experiments with betulin

Promising protocol for in vivo experiments wit...

Pharmacology and Toxicology
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librarian
13 views
Discovery and structure-activity relationship analysis of 2-Pyridyl Thienopyrimidine derivatives as promising therapeutic candidates for the treatment of Buruli ulcer

Discovery and structure-activity relationship ...

Pharmacology and Toxicology
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Fabrice Boyom
13 views
Theanine boosts frontal theta and hippocampal beta and gamma oscillations for familiarity in object recognition

Theanine boosts frontal theta and hippocampal ...

Pharmacology and Toxicology
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Nobuyoshi Matsumoto
8 views
High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells

High-resolution imaging reveals a cascade of i...

Pharmacology and Toxicology
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Pranesh Padmanabhan
10 views
Screening for cryoprotective agent toxicity and toxicity reduction in mixtures at subambient temperatures

Screening for cryoprotective agent toxicity an...

Pharmacology and Toxicology
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librarian
10 views
A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant Klebsiella pneumoniae Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms

A Mechanism Based Pharmacokinetic/Pharmacodyna...

Pharmacology and Toxicology
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librarian
12 views
Synaptic Toxicity of OGA Inhibitors and the Failure of Ceperognastat

Synaptic Toxicity of OGA Inhibitors and the Fa...

Pharmacology and Toxicology
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librarian
13 views
Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms

Role of adipocyte angiotensinogen or angiotens...

Pharmacology and Toxicology
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librarian
11 views
Advanced Cardiac Organoid Model for Studying Doxorubicin-Induced Cardiotoxicity

Advanced Cardiac Organoid Model for Studying D...

Pharmacology and Toxicology
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Xian Wu
13 views
High-Throughput Evaluation of Cryoprotective Agents for Mixture Effects That Reduce Toxicity

High-Throughput Evaluation of Cryoprotective A...

Pharmacology and Toxicology
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librarian
11 views
Evaluation of the Basis and Performance of Simple Allometry for Predictions of Clearance and Oral Clearance in Humans and Improvement Potential with Added In Silico Predictions

Evaluation of the Basis and Performance of Sim...

Pharmacology and Toxicology
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librarian
14 views
Anti-Sense Oligonucleotide as a Therapeutic for Synucleinopathies: Pharmacokinetic, Safety and Efficacy Evaluation

Anti-Sense Oligonucleotide as a Therapeutic fo...

Pharmacology and Toxicology
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librarian
20 views
Hybrid Population PK-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease

Hybrid Population PK-Machine Learning Modeling...

Pharmacology and Toxicology
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librarian
17 views
Consumption of clinically relevant cannabidiol doses during pregnancy alters postnatal behavior in offspring

Consumption of clinically relevant cannabidiol...

Pharmacology and Toxicology
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librarian
14 views
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