Pharmacology and Toxicology

Orally Bioavailable SARS-CoV-2 Protease Inhibitors Bearing a Hydroxymethyl Ketone Warhead

Orally Bioavailable SARS-CoV-2 Protease Inhibi...

Pharmacology and Toxicology
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librarian
44 views
A Cherry-Flavoured E-Cigarette Adduct, BPGA, Reprograms Alveolar Epithelial Cell Fate Through Epithelial-to-Mesenchymal Transition and Evasion of Apoptosis

A Cherry-Flavoured E-Cigarette Adduct, BPGA, R...

Pharmacology and Toxicology
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librarian
53 views
ERRγ deletion in podocytes accelerates aging related kidney disease

ERRγ deletion in podocytes accelerates aging r...

Pharmacology and Toxicology
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librarian
42 views
Comparative metabolism of the Alternaria toxins altenuene and tentoxin in rat and human primary hepatocytes

Comparative metabolism of the Alternaria toxin...

Pharmacology and Toxicology
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librarian
52 views
Cyclic Peptides Target CAPON and Modulate Cellular Responses under Alzheimers Disease-Relevant Stress

Cyclic Peptides Target CAPON and Modulate Cell...

Pharmacology and Toxicology
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librarian
44 views
Integrated luminescence and phenotypic profiling for drug discovery in a zebrafish model of Marfan syndrome

Integrated luminescence and phenotypic profili...

Pharmacology and Toxicology
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librarian
41 views
Activation by statins unveils two putative agonist binding sites in the pore domain of TRPA1

Activation by statins unveils two putative ago...

Pharmacology and Toxicology
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librarian
60 views
Ramelteon facilitates hippocampal ripple occurrence and amplitude in mice

Ramelteon facilitates hippocampal ripple occur...

Pharmacology and Toxicology
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librarian
50 views
Systematic toxicological study of PFOS/PFOA co-exposure driving prostate cancer: Core target identification, TME immune remodeling, and combination drug prediction

Systematic toxicological study of PFOS/PFOA co...

Pharmacology and Toxicology
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Jian SHI
49 views
Virtual screening and zebrafish phenotype-based evaluation argues against repurposing 4-phenylbutyrate for STXBP1-relateddisorders

Virtual screening and zebrafish phenotype-base...

Pharmacology and Toxicology
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Scott Baraban
48 views
Reversible in vivo regulation of drug metabolizing enzyme CYP1A2 activity through a dTAG knock-in strategy

Reversible in vivo regulation of drug metaboli...

Pharmacology and Toxicology
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librarian
55 views
Railway Catenary Sparking as a Source of Toxic Copper Ultrafine Particles: Evidence from Realistic In Vitro Inhalation Exposure

Railway Catenary Sparking as a Source of Toxic...

Pharmacology and Toxicology
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Sebastiano Di Bucchianico
50 views
Sex-specific amplification of IKr-blocker-induced action potential prolongation by reduced female IKs repolarization reserve: a computational study using the O'Hara-Rudy human ventricular model

Sex-specific amplification of IKr-blocker-indu...

Pharmacology and Toxicology
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Tarun Aadithya Raghavan
45 views
Deciphering the Caffeine-Specific Neuroprotective Axis: Comparative Docking and Pharmacokinetic Evaluation of the Coffee Phytocomplex

Deciphering the Caffeine-Specific Neuroprotect...

Pharmacology and Toxicology
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librarian
55 views
Acute Exposure to Perfluorooctanoic Acid (PFOA) During Cardiomyogenesis disrupts Transcriptional and Electrophysiological Profiles in Differentiated Myocytes

Acute Exposure to Perfluorooctanoic Acid (PFOA...

Pharmacology and Toxicology
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librarian
57 views
Model-supported patient stratification using multi-objective synergy optimization in combination therapy

Model-supported patient stratification using m...

Pharmacology and Toxicology
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librarian
56 views
Development of approaches to overcome the drop in hematocrit when implementing mononuclear phagocyte system cytoblockade in vivo used to prolong the circulation of nanoparticles in the blood

Development of approaches to overcome the drop...

Pharmacology and Toxicology
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Elizaveta Mochalova
59 views
Tocilizumab induces significant changes in longitudinal proteomes of blood serum from patients with severe COVID-19 pneumonia

Tocilizumab induces significant changes in lon...

Pharmacology and Toxicology
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librarian
59 views
Effects of the Mu Opioid Receptor Positive Allosteric Modulator BMS-986122 On Opioid Efficacy in Rat Neuropathic Pain States

Effects of the Mu Opioid Receptor Positive All...

Pharmacology and Toxicology
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John Traynor
59 views
Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1

Development of NanoBRET cellular target engage...

Pharmacology and Toxicology
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librarian
61 views
Mutation-Induced Pocket Deactivation: How Ser353/Pro245 Alters KCa2.2 vs KCa3.1 Ligand Selectivity

Mutation-Induced Pocket Deactivation: How Ser3...

Pharmacology and Toxicology
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Oliver Koch
58 views
Serine Stabilizes SLC7A11 and Enhances Cystine Influx to Protect Against Acute Pancreatitis

Serine Stabilizes SLC7A11 and Enhances Cystine...

Pharmacology and Toxicology
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Dan Du
52 views
Hex-MASP for Mapping the Whole-tissue Spatial Proteome and the Intra-brain Distribution of Monoclonal Antibodies

Hex-MASP for Mapping the Whole-tissue Spatial ...

Pharmacology and Toxicology
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Jun Qu
54 views
Protein Age Bias in Target Degradation by PROTACs

Protein Age Bias in Target Degradation by PROTACs

Pharmacology and Toxicology
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librarian
57 views
Phosphoproteomics in Daphnia magna as a tool to decipher molecular mechanisms in ecotoxicological studies

Phosphoproteomics in Daphnia magna as a tool t...

Pharmacology and Toxicology
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Thomas Fröhlich
59 views
Intraventricular infusion to circumvent the blood-brain barrier to gemcitabine.

Intraventricular infusion to circumvent the bl...

Pharmacology and Toxicology
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Bruno CHAUFFERT
61 views
TRPA1 channel activation by synthetic lipid nanoparticles

TRPA1 channel activation by synthetic lipid na...

Pharmacology and Toxicology
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librarian
62 views
Extreme Hydrophobicity of Cytotoxic Drugs Enables Design of Next Generation Antibody-Drug Conjugates Nanotherapeutics

Extreme Hydrophobicity of Cytotoxic Drugs Enab...

Pharmacology and Toxicology
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librarian
66 views
Inhibition of oogenic JNK preserves fertility and ovarian hormones during DNA-damaging cancer therapy

Inhibition of oogenic JNK preserves fertility ...

Pharmacology and Toxicology
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librarian
75 views
Lysophosphatidic Acid (LPA) Salivary Species Detection and Whole-mount LPA Receptor Localization in Mouse Salivary Gland

Lysophosphatidic Acid (LPA) Salivary Species D...

Pharmacology and Toxicology
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librarian
75 views
Selective targeting of the oligodendroglial GPR17 receptor improves myelin integrity and motor function in female SOD1G93A mice

Selective targeting of the oligodendroglial GP...

Pharmacology and Toxicology
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librarian
67 views
Otenabant is a Selective Antagonist of Human PIEZO1

Otenabant is a Selective Antagonist of Human P...

Pharmacology and Toxicology
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librarian
86 views
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