Sheng, W.; Dong, T.; Gao, W.; Yi, T.; Gong, Y.

CD4+ T cells has critical roles in anti-tumor immunity and its differentiation is known to be regulated by the nuclear receptor co-repressor 1 (NCOR1). Previous study suggested that high CD4+ T cells is associated with favorable prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). However, the prognostic significance of NCOR1 in PDAC is still missing. In this study, the pathological impact of NCOR1 and CD4 has been analysed by multiplex immuohistochemistry in 100 PADC patients. NCOR1 expression in tertiary lymphoid organs is positively associated with the good prognosis of PDAC patients, while its expression in tumor tissue is not. Furthermore, the presence of NCOR1+/CD4+ T cells in tertiary lymphoid organs predicts a favorable prognosis in PDAC. Together, our data highlighted the tumor suppressive role of NCOR1+/CD4+ T cells in PDAC, and future study is needed to verify its biological function.