Pedrola, J. A.; Dekker, F. A.; Guttmann, K.; van Leeuwen, L. M.; Singh, S.; Mayer, G.; Garfagnini, T.; Friedler, A.; Rudiger, S. G. D.

Neurodegenerative diseases, such as Alzheimer Disease, Parkinson Disease, Huntington Disease, are characterised by accumulation of amyloid fibrils. To date, there is no cure for these diseases, and it is of great importance to develop disease-modifying therapies. Recently, we discovered the FibrilPaint1 peptide, a specific amyloid binder. Here we introduce a class of FibrilPaint1 derivatives that bind to fibrils. The alterations include variation of the charge, termini and order of residues. As a result, we generated a class of peptides with general fibril-binding properties and with the potential for further adaptation, such as linkage to multiple dyes, optimisation for specific protein and aggregate strains, or adaptation for targeted protein degradation strategies. Thus, FibrilPaint peptides are a class of promising drug leads for targeting amyloid fibrils for therapeutic and diagnostic purposes.