Biochemistry

Structural and kinetic insights into a metagenomics-derived Cas12a with high specificity

Structural and kinetic insights into a metagen...

Biochemistry
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Tyler Dangerfield
2 views
Conformational Expansion Underlies the Evolutionary Emergence of Redox Sensitivity in Vertebrate Glucokinases

Conformational Expansion Underlies the Evoluti...

Biochemistry
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librarian
4 views
Chronic elevation of 1.25(OH)2D enhances cholesterol excretion through coordinated regulation of hepatic and intestinal elimination pathways

Chronic elevation of 1.25(OH)2D enhances chole...

Biochemistry
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Chiaki Abe
2 views
Specificity Profiling of the RhoGEF Domain of EhFP10 with EhRho GTPases Involved in Cytoskeleton Remodeling

Specificity Profiling of the RhoGEF Domain of ...

Biochemistry
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Samudrala Gourinath
3 views
Crude Fucus vesiculosus fucoidan demonstrates superior SARS-CoV-2 antiviral activity compared to its pure form: binding kinetics and functional studies

Crude Fucus vesiculosus fucoidan demonstrates ...

Biochemistry
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librarian
4 views
PCanPIE: A group I intron platform for efficient circRNA synthesis at ambient temperatures

PCanPIE: A group I intron platform for efficie...

Biochemistry
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librarian
3 views
The Impact of Dysregulated Lipid Metabolism on the Gut-Brain Axis in Patients with Intracerebral Hemorrhage

The Impact of Dysregulated Lipid Metabolism on...

Biochemistry
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Guoping Wang
2 views
Evaluating β-glucanases as cell wall-permeabilising agents against Phytophthora agathidicida oospores

Evaluating β-glucanases as cell wall-permeabil...

Biochemistry
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librarian
6 views
Evolutionary insights into bilin biosynthesis: Functional characterization of pre-PcyA enzymes

Evolutionary insights into bilin biosynthesis:...

Biochemistry
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librarian
5 views
Hero11 Unlocks TDP-43 Condensate Fluidity via Targeting Inter-Helical Interactions

Hero11 Unlocks TDP-43 Condensate Fluidity via ...

Biochemistry
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librarian
5 views
Redox Regulation in O2-Tolerant Hydrogenases: Insights from two homologues.

Redox Regulation in O2-Tolerant Hydrogenases:...

Biochemistry
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Alexey Silakov
6 views
Molecular characterization of the effector-immunity pair Rhs2-SciX from Salmonella Typhimurium

Molecular characterization of the effector-imm...

Biochemistry
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librarian
4 views
Divergent CRD-Dependent Mechanisms Govern RAS Isoform-Selective Recruitment of CRAF and ARAF

Divergent CRD-Dependent Mechanisms Govern RAS ...

Biochemistry
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librarian
5 views
Redesign of energetically frustrated regions rescues function in defective T4 clamp loaders

Redesign of energetically frustrated regions r...

Biochemistry
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librarian
6 views
Substrate-dependent crosslinking by the cytochrome P450 from aminopyruvatide biosynthesis

Substrate-dependent crosslinking by the cytoch...

Biochemistry
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librarian
7 views
Context-dependent peptide recognition shapes tyrosine kinase substrate specificity beyond consensus motifs

Context-dependent peptide recognition shapes t...

Biochemistry
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Jerome Fox
5 views
Conformational Diversity and Substrate Specificity are Decoupled in Ancestral and Extant Glucokinases

Conformational Diversity and Substrate Specifi...

Biochemistry
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librarian
6 views
Heterogeneous reconstruction algorithms for cryoEM achieve limited particle classification accuracy on real benchmark datasets

Heterogeneous reconstruction algorithms for cr...

Biochemistry
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Laurel Kinman
7 views
dCas9 metabolic enzyme fusions modulate global and locus specific gene expression

dCas9 metabolic enzyme fusions modulate global...

Biochemistry
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librarian
12 views
Linking the kinetic mechanism to structural dynamics required for nucleotide hydrolysis by an alphavirus nsP2 RNA helicase

Linking the kinetic mechanism to structural dy...

Biochemistry
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librarian
9 views
Structural Co-optation and Loss-of-function Underlie the Evolution of Regulatory Novelty in the Glucokinase Regulatory Protein

Structural Co-optation and Loss-of-function Un...

Biochemistry
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librarian
7 views
AAV2 Crosslinks Actin Filaments: Implications for AAV Gene Therapy Vector Design

AAV2 Crosslinks Actin Filaments: Implications ...

Biochemistry
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librarian
8 views
Molecular architecture of meiotic pro-crossover factor HEI10 reveals coupling of higher-order assembly and ubiquitin chain formation

Molecular architecture of meiotic pro-crossove...

Biochemistry
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librarian
13 views
Molecular basis for the role of Ripr in Plasmodium falciparum invasion of human erythrocytes

Molecular basis for the role of Ripr in Plasmo...

Biochemistry
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Stephen Scally
11 views
Localized heme sensing through a ternary molecular glue

Localized heme sensing through a ternary molec...

Biochemistry
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librarian
19 views
A de novo CO2 Reductase Featuring a Cysteine-Ligated Cobalt Porphyrin Cofactor

A de novo CO2 Reductase Featuring a Cysteine-L...

Biochemistry
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librarian
23 views
The development of ToF-SIMS for in-situ glycosaminoglycan analysis

The development of ToF-SIMS for in-situ glycos...

Biochemistry
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librarian
14 views
Hydrophobic pocket engineering of arylmalonate decarboxylase expands its substrate scope towards the synthesis of the (R)-enantiomers of sterically hindered carboxylic acids

Hydrophobic pocket engineering of arylmalonate...

Biochemistry
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librarian
14 views
The turn less taken: Investigating patterns in β-turn dynamics using large-scale molecular dynamics data

The turn less taken: Investigating patterns in...

Biochemistry
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librarian
13 views
A CYFIP1-Inspired Peptidomimetic Modulates eIF4E-Dependent Translational Control in Cancer and Neurodevelopmental Disorders

A CYFIP1-Inspired Peptidomimetic Modulates eIF...

Biochemistry
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Alice Romagnoli
15 views
Rhodopsin is a tunable capacitor buffering the toxic, desensitizing retinoids of the vertebrate eye

Rhodopsin is a tunable capacitor buffering the...

Biochemistry
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Gianni Castiglione
15 views
LonP1 chaperone-like activity is ATPase independent and is mediated by its N-domain

LonP1 chaperone-like activity is ATPase indepe...

Biochemistry
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librarian
15 views
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