Biochemistry

The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2

The pathogenic E139D mutation stabilizes a non...

Biochemistry
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librarian
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PGM1 deficiency disrupts sarcomere and mitochondrial function in a stem-cell cardiomyocyte model

PGM1 deficiency disrupts sarcomere and mitocho...

Biochemistry
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librarian
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Automodification of N-terminal serine residues in PARP2 impacts PARP2 release from DNA damage sites

Automodification of N-terminal serine residues...

Biochemistry
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librarian
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Cryo-electron microscopy structures of a high-affinity zinc ABC transporter

Cryo-electron microscopy structures of a high-...

Biochemistry
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Qun Liu
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DNA Polymerase α has pyrimidine dimer translesion activity that is suppressed during normal replication

DNA Polymerase α has pyrimidine dimer transles...

Biochemistry
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Grant Schauer
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Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion

Targeted degradation of USP7 in solid cancer c...

Biochemistry
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librarian
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The mechanism of cross-talk between histone H2B ubiquitination and H3 methylation by Dot1L

The mechanism of cross-talk between histone H2...

Biochemistry
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Arv
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Rational design of oxidation-resistant antibodies through local electrostatic modulation

Rational design of oxidation-resistant antibod...

Biochemistry
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librarian
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A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC Oligomerization Inhibitor

A Membrane-Disruptive Action of VBIT-4 Challen...

Biochemistry
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Lucie Bergdoll
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QUANTITATIVE PROTEOMICS OF PLASMA EXTRACELLULAR VESICLES REVEALS A TTR - PLASMINOGEN NETWORK IN ATTR CARDIAC AMYLOIDOSIS

QUANTITATIVE PROTEOMICS OF PLASMA EXTRACELLULA...

Biochemistry
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Sandrine Bourgoin-Voillard
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Organism-wide spatiotemporal profiling of gene expression utilizing a X-CreERT2/Ai9 tracing system

Organism-wide spatiotemporal profiling of gene...

Biochemistry
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Guozhi Xiao
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Toward pharmacologic therapy for glioblastoma: Identifying inhibitors of very long-chain acyl-CoA synthetase 3 (ACSVL3)

Toward pharmacologic therapy for glioblastoma:...

Biochemistry
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librarian
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Quantitative Thermodynamic Characterization of Self-Assembling RNA Nanostructures

Quantitative Thermodynamic Characterization of...

Biochemistry
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librarian
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Accurate and Fast Protein Acylation Identification by Eliminating Position Effects of Cyclic Immonium Ions with Stepped HCD

Accurate and Fast Protein Acylation Identifica...

Biochemistry
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librarian
1 view
PCNA is a Nucleotide Exchange Factor for the Clamp Loader ATPase Complex

PCNA is a Nucleotide Exchange Factor for the C...

Biochemistry
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librarian
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Structural basis for TORC2 activation

Structural basis for TORC2 activation

Biochemistry
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Robbie Loewith
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DNA polymerase α-primase can function as a translesion DNA polymerase

DNA polymerase α-primase can function as a tra...

Biochemistry
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Michael O'Donnell
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Urolithin B reduces the aggregate load of islet amyloid polypeptide in Caenorhabditis elegans

Urolithin B reduces the aggregate load of isle...

Biochemistry
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librarian
1 view
Oxidant-mediated amino acid conversion of angiotensin II: Effects on gene expression in vascular smooth muscle cells.

Oxidant-mediated amino acid conversion of angi...

Biochemistry
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Yuichiro Suzuki
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Temporal Control of CRISPR-Cas9 Activity Using Bio-orthogonal Chemistry.

Temporal Control of CRISPR-Cas9 Activity Using...

Biochemistry
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Maksim Royzen
2 views
Ser500 phosphorylation acts as a conformational switch to prime eEF-2K for activation

Ser500 phosphorylation acts as a conformationa...

Biochemistry
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Ranajeet Ghose
1 view
Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions

Towards the Development of Isoenergetic Peptid...

Biochemistry
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librarian
3 views
SARS-CoV-2 spike protein amyloid fibrils impair fibrin formation and fibrinolysis

SARS-CoV-2 spike protein amyloid fibrils impai...

Biochemistry
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librarian
2 views
Phase-Specific Antibiotic Resistance Mechanisms in an Escherichia coli B Strain

Phase-Specific Antibiotic Resistance Mechanism...

Biochemistry
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Tonya Zeczycki
1 view
A viral SAVED protein with ring nuclease activity degrades the CRISPR second messenger cA4

A viral SAVED protein with ring nuclease activ...

Biochemistry
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librarian
1 view
Human CXCL17 Activates and Binds to Fish GPR25 Orthologs

Human CXCL17 Activates and Binds to Fish GPR25...

Biochemistry
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librarian
42 views
Titania Nanoparticle Regulate Innate Immunity

Titania Nanoparticle Regulate Innate Immunity

Biochemistry
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librarian
37 views
Proteomics- and BRET-screens identify SPRY2 as Ras effector that impacts its membrane organisation

Proteomics- and BRET-screens identify SPRY2 as...

Biochemistry
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librarian
35 views
Analysis of apo and citraconate-bound hACOD1 (hIRG1) by X-ray crystallography and NMR spectroscopy: structural insights for developing chemotherapeutic agents

Analysis of apo and citraconate-bound hACOD1 (...

Biochemistry
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librarian
36 views
Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicity

Metabolism of epigenetic ribonucleosides leads...

Biochemistry
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librarian
35 views
M. tuberculosis meets European Lead Factory - identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography

M. tuberculosis meets European Lead Factory - ...

Biochemistry
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librarian
48 views
Structural basis for NONO specific modification by the α-chloroacetamide compound (R)-SKBG-1

Structural basis for NONO specific modificatio...

Biochemistry
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librarian
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