Instantaneous Flow Analysis of Contractile Cytoskeletal Structures Affected by the Dysregulation of Kinesin and Tropomyosin Motors
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Instantaneous Flow Analysis of Contractile Cytoskeletal Structures Affected by the Dysregulation of Kinesin and Tropomyosin Motors
Matov, A.
AbstractThis manuscript explores, for the first time, in a quantitative way, the changes occurring in epithelial cells after upregulation of a stronger and a weaker isoform of the actin binding protein tropomyosin. The main cytoskeletal proteins, actin and tubulin, regulate cellular homeostasis in normal physiology and in disease. As such, the modulation of actin and microtubule contractility and dynamics could deliver significant clinical results in the treatment of cancers and neurodegenerative diseases.