Identification of mCMQ069, a novel antimalarial with potential for a single-dose cure and/or 28-day chemoprevention
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Identification of mCMQ069, a novel antimalarial with potential for a single-dose cure and/or 28-day chemoprevention
Gupta, A. K.; Pedroarena, J.; Nazarian, A.; Antonova-Koch, J.; Weiss, F.; Kumpornsin, K.; Chi, V.; Woods, A. K.; Lee, K.-J.; Joseph, S. B.; Li, S.; Brittain, J.; Hostos, E. D.; Duffy, J.; Cooper, A.; Schultz, P. G.; McNamara, C. W.; Chatterjee, A. K.
AbstractIn efforts towards eliminating malaria, a discovery program was initiated to identify a novel antimalarial using KAF156 as a starting point. Following the most recent TCP/TPP guidelines, we have identified mCMQ069 with a predicted single oral dose for treatment (~40-106 mg) and one-month chemoprevention (~96-216 mg). We have improved unbound MPC and predicted human clearance by 18-fold and 10-fold respectively when compared to KAF156.