Mou, X.; Nie, P.; Chen, R.; Cheng, Y.; Wang, G.-Z.

Feeding disruption is intimately associated with numerous diseases, yet its molecular mechanisms remain to be elucidated in circadian biology. We discovered that in the liver of adult mice, feeding disruption can lead to a substantial increase in disease modules in the transcriptome. This increase in disease modules occurs far earlier than the individual\'s aging and disease onset. In contrast, calorie restriction significantly reduces the formation of disease modules. This offers a critical missing link between feeding disruption and the molecular systems mechanisms of disease.