Shikauchi, Y.; Aoki, R.; Itahashi, T.; Shimizu, M.; Naoe, T.; Okimura, T.; Ota, H.; Hashimoto, R.-i.; Nakamura, M.

Intrinsic neural timescales (INTs) index the temporal decay of neural activity and form a cortical hierarchy from fast sensorimotor to slow transmodal regions. Altered INTs have been reported in autism spectrum disorder (ASD), but it remains unclear whether the hierarchical organization is preserved and how individual variability along this hierarchy relates to sensory traits. Using resting-state fMRI from 182 participants (67 ASD, 115 typically developed controls (TDC)), we estimated INT at each cortical vertex from the autocorrelation half-life and averaged these values across four five-minute runs per participant. Vertex-wise INTs were then averaged within predefined cortical parcels and large-scale functional networks for subsequent analyses. The cortical INT hierarchy was preserved in ASD, showing comparable sensorimotor-to-transmodal hierarchy in both groups. However, regions operating at longer timescales showed prolonged INTs in ASD, and such tendency increased systematically along the hierarchy. No vertex, parcel, or network survived correction of multiple comparisons, indicating that observed alterations followed a distributed hierarchical trend rather than a focal pattern. To disentangle group-level differences from inter-individual variability, we next modeled each participant's parcel-wise INT profile relative to a TDC-derived group-averaged template. At the individual level, decomposition of INT profiles revealed that global shifts and hierarchical scaling primarily reflected demographic variation (plimarily sex) rather than diagnostic group membership. After accounting for these components, residual deviations from theTDC-derived cortical INT hierarchy showed a modest association with sensory traits characterized by reduced sensory registration. Together, these findings indicate that while the large-scale hierarchical organization of cortical temporal dynamics is largely preserved in ASD, individual-specific deviations from this hierarchy may contribute to variability in sensory experience beyond group-level differences.