Barranco, J.; Luyken, A. K.; Stachs, O.; Langner, S.; Franceschiello, B.; Bach Cuadra, M.

This study addresses the need for accurate 3D segmentation of the human eye and orbit from MRI to improve ophthalmic diagnostics. Past efforts focused on small sample sizes and varied imaging methods. Here, two techniques (atlas-based registration and supervised deep learning) are tested for automated segmentation on a large T1-weighted MRI dataset. Results show accurate segmentations of the lens, globe, optic nerve, rectus muscles, and fat. Additionally, the study automates the estimation of axial length, a key biomarker.