David, S.; Diaz Caballero, J.; Couto, N.; Abudahab, K.; Fareed-Alikhan, N.; Yeats, C.; Underwood, A.; Molloy, A.; Connor, D.; Shane, H. M.; Ashton, P. M.; Grundmann, H.; Holden, M. T.; Feil, E. J.; Sia, S. B.; Donado-Godoy, P.; Lingegowda, R. K.; Okeke, I. N.; Argimon, S.; Aanensen, D. M.; NIHR Global Health Research Unit on Genomics and enabling data for the Surveillance of AMR,

Background Whole genome sequencing (WGS) is increasingly supporting routine pathogen surveillance at local and national levels, providing comparable data that can inform on the emergence and spread of antimicrobial resistance (AMR) globally. However, the potential for shared WGS data to guide interventions around AMR remains under-exploited, in part due to challenges in collating and transforming the growing volumes of data into timely insights. We present an interactive platform, amr.watch (https://amr.watch), that enables interrogation of AMR trends from public WGS data on an ongoing basis to support research and policy. Methods The amr.watch platform incorporates, analyses and visualises high-quality WGS data from WHO-defined priority bacterial pathogens. Analytics are performed using community-standard methods with bespoke species-specific curation of AMR mechanisms. Findings By 31 March 2025, amr.watch included data from 620,700 pathogen genomes with geotemporal information, with highly variable representation of different species and geographic regions. By integrating WGS data with sampling information, amr.watch enables users to assess geotemporal trends among genotypic variants (e.g. sequence types) and AMR mechanisms, with implications for interventions including antimicrobial prescribing and drug and vaccine development. Interpretation amr.watch is an information platform for scientists and policy-makers delivering ongoing situational awareness of AMR trends from genomic data. As broad adoption of WGS continues, amr.watch is positioned to monitor both pathogen populations and our global efforts in genomic surveillance, guiding control strategies tailored to each pathogen\'s characteristics.