Austin-Muttitt, K.; David, B. R.; Sassi, M.; Agarwal, R.; Sabedot, T.; Jones, J. R.; Cuoco, M. S.; Jenkins, B. J.; Roberts, L. D.; Harris, L.; Kieronczyk, N.; Han, G.; Hitchings, M. D.; Donaghy, P. C.; Yarnall, A. J.; Thornton, C. A.; Mohamed, B.; Morgan, A. H.; Thomas, F.; Jones, N.; Gage, F. H.; Davies, J. S.

T cells modulate disease associated neuroinflammation in Parkinson's disease (PD). We report that circulating CD4+ T cells from people with PD have a dysregulated transcriptional and cytokine response to fasting and refeeding and an altered metabolic profile. The CD4+ T cell secretome mediates a metabolic program in neurons that is impaired in PD, revealing dysfunctional neuro-immune signalling that may contribute to disease pathology.