Gagnon, L.; Moreau, C.; Laprise, C.; Girard, S. L.

In response to the current challenge in genetic studies to make new associations, we advocate for a shift toward leveraging population fine-scale structure. Our exploration brings to light distinct fine-structure within populations having undergone a founder effect, challenging the prior perception of homogeneity. This underscores that smaller, but well-defined cohorts, demonstrate an important increase in rare variant frequencies, offering a promising avenue for new genetic variants\' discovery.