Suresh Kumar, Dhanyashri Guruparan, Pavithren Aaron, Philemon Telajan, Kavinesh Mahadevan, Dinesh Davagandhi, Ong Xin Yue

Deep learning has become a powerful tool in computational biology, revolutionising the analysis and interpretation of biological data over time. In our article review, we delve into various aspects of deep learning in computational biology. Specifically, we examine its history, advantages, and challenges. Our focus is on two primary applications: DNA sequence classification and prediction, as well as protein structure prediction from sequence data. Additionally, we provide insights into the outlook for this field. To fully harness the potential of deep learning in computational biology, it is crucial to address the challenges that come with it. These challenges include the requirement for large, labelled datasets and the interpretability of deep learning models. The use of deep learning in the analysis of DNA sequences has brought about a significant transformation in the detection of genomic variants and the analysis of gene expression. This has greatly contributed to the advancement of personalised medicine and drug discovery. Convolutional neural networks (CNNs) have been shown to be highly accurate in predicting genetic variations and gene expression levels. Deep learning techniques are used for analysing epigenetic data, including DNA methylation and histone modifications. This provides valuable insights into metabolic conditions and gene regulation. The field of protein structure prediction has been significantly impacted by deep learning, which has enabled accurate determination of the three-dimensional shape of proteins and prediction of their interactions. The future of deep learning in computational biology looks promising. With the development of advanced deep learning models and interpretation techniques, there is potential to overcome current challenges and further our understanding of biological systems.