Public Health Response to Pan-Resistant Pseudomonas aeruginosa Sequence Type 309 with Tandem Guiana Extended Spectrum Beta Lactamases Genetic Characterization and In Vivo Efficacy Assessment using Translational Murine Model.

Lloyd, T.; Gill, C. M.; Aquino Herrera, J.; Heaton, D.; Shemsu, M.; Trivedi, K. K.; Gorzalski, A.; Bender, M.; Pandori, M.; Varghese, V.; Nicolau, D. P.

Through phenotypic and genetic profiling, we identified the first pan resistant Pseudomonas aeruginosa high-risk sequence type 309 (ST-309) with Guiana Extended Spectrum {beta}-Lactamase (GES) in California, prior to a national outbreak of VIM-GES Pseudomonas aeruginosa (1). Our findings highlight detection and use of the translational murine model provide treatment implications for this emerging Pseudomonas aeruginosa.